We are pleased to announce the publication of a new research article related to GuNA technology in Organic & Biomolecular Chemistry.

The article includes contributions from Luxna Biotech researchers and reports an improved guanidine protecting group for the efficient synthesis of GuNA[t-Bu]-modified antisense oligonucleotides. The findings contribute to the advancement of modified nucleic acid technologies and enable efficient and scalable production of GuNA[t-Bu]-modified oligonucleotides.

【Publication】

・Authors
Shrestha AR, Hayashi J, Kajino R, Hatanaka R, Horie N, Yamaguchi T, Obika S, Umemoto T.

・Article Title
An improved guanidine protecting group for the efficient synthesis of GuNA[t-Bu]-modified antisense oligonucleotides.

・Journal
Organic & Biomolecular Chemistry, 2026.

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